Theralase Discovers Anti-Cancer Drug Fluoresces in Tissue
May 14, 2015 (Source: Accesswire) — Theralase Technologies Inc. (“Theralase” or the “Company”) (TSX Venture: TLT) (PINKSHEETS: TLTFF), a leading biotechnology manufacturer focused on commercializing medical technologies to eliminate pain and destroy cancer, has discovered that its lead anti-cancer drug, TLD-1433, emits a fluorescent signature when light activated in a Non-Muscle Invasive Bladder Cancer (“NMIBC“) animal model.
The advantages of this discovery are three fold:
1) It can be used as a diagnostic tool for the oncologist to detect the presence of cancer cells and micro-metastases too small to be seen by the human eye.
2) It can be used to determine sufficient uptake of TLD-1433 into the cancer cells
3) After light activation, it can determine if the cancer cells that have absorbed the drug have been destroyed.
Theralase intends to use this new discovery in the treatment of NMIBC.
Clinical Treatment Protocol of NMBIC with Photo Dynamic Therapy:
– Intravesical installation of TLD-1433 into the bladder via cystoscope
– Allow approximately sixty minutes for the drug to diffuse into the bladder cancer cells
– Flush the bladder and refill with water
– Visual analysis by the uro-oncologist to check for fluorescence to indicate the presence of cancer cells, their specific location and whether sufficient quantities of the drug have been absorbed to proceed to light activation
– Light activation for approximately thirty minutes
– Post treatment analysis to check for no fluorescence indicating that all bladder cancer cells that absorbed the drug have been destroyed
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Dr. Arkady Mandel, Chief Scientific Officer stated that, “TLD-1433-based fluorescence optical imaging technology represents an exciting opportunity in employing this technology to systematically detect and destroy cancer cells, improving the specificity of disease detection and treatment. The technology offers relative ease of integration into the operating room environment with instruments commonly used in a minimal invasive urological procedure. This technology holds promise to revolutionize our clinical paradigm in guiding medical procedures and can provide oncological surgeons and urologists with intraoperative capability to visualize and distinguish diseased from healthy tissue with cellular and molecular specificity.”
Roger Dumoulin-White, President and CEO stated, “Theralase continues to make ground breaking discoveries in our pursuit for the safe and effective treatment of cancer, commencing with NMIBC. The entire Theralase team looks forward to proving the safety, tolerability and efficacy of this technology in a Health Canada Phase Ib human clinical study.”
The Video Announcement is available in the link below:
About Theralase Technologies Inc.
Theralase Technologies Inc. (“Theralase(R)“) (TSX Venture: TLT) (PINKSHEETS: TLTFF) in its Therapeutic Laser Technology Division designs, manufactures and markets patented super-pulsed laser technology indicated for the: elimination of pain, reduction of inflammation and dramatic acceleration of tissue healing for numerous nerve, muscle and joint conditions. Theralase’s Photo Dynamic Therapy Division researches and develops specially designed molecules called Photo Dynamic Compounds, which are able to localize to the cancer cells and then when laser light activated, effectively destroy them.
Theralase Technologies Inc. was recognized as a TSX Venture 50(R) company in 2015. TSX Venture 50 is a trademark of TSX Inc. and is used under license.
This press release contains forward-looking statements, which reflect the Company’s current expectations regarding future events. The forward-looking statements involve risks and uncertainties. Actual results could differ materially from those projected herein. The Company disclaims any obligation to update these forward-looking statements.
Neither TSX Venture Exchange nor its Regulation Services Provider (as that term is defined in the policies of the TSX Venture Exchanges) accepts responsibility for the adequacy or accuracy of this release.
Raj Shah has professional experience working for over a half a dozen years at financial firms such as Merrill Lynch and First Allied Securities Inc., ... <Read more about Raj Shah>